Fibronectins in vascular morphogenesis

被引：213

作者：

Astrof, Sophie ^{[1
]}

Hynes, Richard O. ^{[2
]}

机构：

[1] Cornell Univ, Weill Med Coll, Dept Cell & Dev Biol, Dept Med,Greenberg Div Cardiol, New York, NY 10065 USA

[2] MIT, Koch Inst Integrat Canc Res, Howard Hughes Med Inst, Cambridge, MA 02139 USA

来源：

ANGIOGENESIS | 2009年 / 12卷 / 02期

关键词：

Alternative splicing; Angiogenesis; Cardiovascular development; Endothelium; Integrins; Pericyte; Vascular smooth muscle; BLOOD-VESSEL FORMATION; ALTERNATIVELY SPLICED SEGMENTS; SMOOTH-MUSCLE-CELLS; PRE-MESSENGER-RNA; ALPHA-V INTEGRINS; EXTRA DOMAIN-A; TUMOR VASCULATURE; MOUSE EMBRYOS; MICE LACKING; ENDOTHELIAL-CELLS;

D O I：

10.1007/s10456-009-9136-6

中图分类号：

R6 [外科学];

学科分类号：

100210 [外科学];

摘要：

Fibronectin is an extracellular matrix protein found only in vertebrate organisms containing endothelium-lined vasculature and is required for cardiovascular development in fish and mice. Fibronectin and its splice variants containing EIIIA and EIIIB domains are highly upregulated around newly developing vasculature during embryogenesis and in pathological conditions including atherosclerosis, cardiac hypertrophy, and tumorigenesis. However, their molecular roles in these processes are not entirely understood. We review genetic studies examining functions of fibronectin and its splice variants during embryonic cardiovascular development, and discuss potential roles of fibronectin in vascular disease and tumor angiogenesis.

引用

收藏

页码：165 / 175

页数：11

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