6-Amino-6-deoxy-5,6-di-N-(N′-octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid β-Glucosidase

被引：42

作者：

Brumshtein, Boris ^{[2
]}

Aguilar-Moncayo, Matilde ^{[1
]}

Isabel Garcia-Moreno, M. ^{[1
]}

Ortiz Mellet, Carmen ^{[1
]}

Garcia Fernandez, Jose M. ^{[3
]}

Silman, Israel ^{[4
]}

Shaaltiel, Yoseph ^{[5
]}

Aviezer, David ^{[5
]}

Sussman, Joel L. ^{[2
]}

Futerman, Anthony H. ^{[6
]}

机构：

[1] Univ Seville, Dept Quim Organ, Fac Quim, Seville 41012, Spain

[2] Weizmann Inst Sci, Dept Biol Struct, IL-76100 Rehovot, Israel

[3] Univ Seville, CSIC, Inst Invest Quim, Seville 41092, Spain

[4] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

[5] Protalix Biotheropeut, IL-20100 Carmiel, Israel

[6] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

来源：

CHEMBIOCHEM | 2009年 / 10卷 / 09期

关键词：

acid beta-glucosidase; Gaucher disease; guanidine; iminosugars; inhibitors; nojirimycin; X-RAY-STRUCTURE; GLYCOSIDASE INHIBITORS; TRANSITION-STATE; GAUCHER-DISEASE; GLYCOMIMETICS; INSIGHTS; ENZYME; INDOLIZIDINE; CHAPERONES; DESIGN;

D O I：

10.1002/cbic.200900142

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：1480 / 1485

页数：6

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