Challenges and solutions for the delivery of biotech drugs - a review of drug nanocrystal technology and lipid nanoparticles

被引:568
作者
Muller, RH [1 ]
Keck, CM [1 ]
机构
[1] Free Univ Berlin, Dept Pharmaceut Biopharmaceut & Biotechnol, D-12169 Berlin, Germany
关键词
delivery system; solid lipid nanoparticles; nanocrystals; drug targeting; PathFinder; poor solubility;
D O I
10.1016/j.jbiotec.2004.06.007
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Biotechnology allows tailor-made production of biopharmaceuticals and biotechnological drugs; however, many of them require special formulation technologies to overcome drug-associated problems. Such potential challenges to solve are: poor solubility, limited chemical stability in vitro and in vivo after administration (i.e. short half-life), poor bioavailability and potentially strong side effects requiring drug enrichment at the site of action (targeting). This review describes the use of nanoparticulate carriers, developed in our research group, as one solution to overcome such delivery problems, i.e. drug nanocrystals, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and lipid-drug conjugate (LDC) nanoparticles, examples of drugs are given. As a recently developed targeting principle, the concept of differential protein adsorption is described (PathFinder Technology) using as example delivery to the brain. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:151 / 170
页数:20
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