CCK biosynthesis and processing: Recent progress and future challenges

被引：26

作者：

Beinfeld, MC

机构：

来源：

LIFE SCIENCES | 1997年 / 61卷 / 24期

关键词：

CCK; PC1; PC2; post-translational modification of proteins; tyrosine sulfation; carboxypeptidase;

D O I：

10.1016/S0024-3205(97)00644-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The peptide cholecystokinin (CCK), like other peptides which pass through the regulated secretory pathway, undergoes a number of post-translational modifications during its biosynthesis including tyrosine sulfation, endoproteolytic cleavage, and trimming by carboxypeptidases. This minireview summarizes what is known about this process in endocrine cells and in the Cpe(fat)/Cpe(fat) mouse and points out what challenges remain for future research.

引用

页码：2359 / 2366

页数：8

共 43 条

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