The influence of amino acids on the biomineralization of hydroxyapatite in gelatin

被引：68

作者：

Eiden-Assmann, S

Viertelhaus, M

Heiss, A

Hoetzer, KA

Felsche, J

机构：

[1] Univ Konstanz, Fachbereich Chem, D-78457 Constance, Germany

[2] Univ Karlsruhe, Inst Anorgan Chem, D-76128 Karlsruhe, Germany

[3] Univ Hosp Aachen, IZKF BIOMAT, Aachen, Germany

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2002年 / 91卷 / 03期

关键词：

hydroxyapatite; amino acid; morphology; crystallization; gelatin;

D O I：

10.1016/S0162-0134(02)00481-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of pH on the calcium phosphate phase. of Tris and of amino acids, such as aspartic acid, glutamic acid, and serine on hydroxyapatite formation and morphology, were studied in double diffusion experiments, In this system, hydroxyapatite was only formed when the pH was around 7.4 or higher for the duration of the reaction. A decrease in pH resulted in the transformation of hydroxyapatite to octacalcium phosphate. Amino acids and Tris or the buffering capacity of Tris have an effect on the morphology of the synthetic hydroxyapatite. The presence of the additive results in spheres consisting of needles, blades or plates depending on the reaction system. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：481 / 486

页数：6

共 24 条

[1] CRYSTAL PROTEIN INTERACTIONS STUDIED BY OVERGROWTH OF CALCITE ON BIOGENIC SKELETAL ELEMENTS [J].