Structure and function of snake venom cysteine-rich secretory proteins

被引：251

作者：

Yamazaki, Y ^{[1
]}

Morita, T ^{[1
]}

机构：

[1] Meiji Pharmaceut Univ, Dept Biochem, Tokyo 2048588, Japan

来源：

TOXICON | 2004年 / 44卷 / 03期

关键词：

cysteine-rich secretory proteins; snake venom; smooth muscle contraction; cyclic nucleotide-gated ion channels; distribution;

D O I：

10.1016/j.toxicon.2004.05.023

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cysteine-rich secretory proteins (CRISPs) are primarily found in the epididymis of mammals and are expressed in diverse organisms. However, the functions of most CRISPs remain unknown. Recent studies reveal that CRISPs are widely distributed in snake venoms and that they inhibit smooth muscle contraction and cyclic nucleotide-gated ion channels. In this review, we discuss recent findings on several snake venom-derived CRISPs. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：227 / 231

页数：5

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