Cell interactions with three-dimensional matrices

被引：765

作者：

Cukierman, E ^{[1
]}

Pankov, R ^{[1
]}

Yamada, KM ^{[1
]}

机构：

[1] NIDCR, Craniofacial Dev Biol & Regenerat Branch, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2002年 / 14卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(02)00364-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Signaling and other cellular functions differ in three-dimensional compared with two-dimensional systems. Cell adhesion structures can evolve in vitro towards in-vivo-like adhesions with distinct biological activities. In this review, we examine recent advances in studies of interactions of fibroblasts with collagen gels and fibronectin-containing matrices that mimic in vivo three-dimensional microenvironments. These three-dimensional systems are illuminating mechanisms of cell-matrix interactions in living organisms.

引用

页码：633 / 639

页数：7

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