Vaccine assembly from surface proteins of Staphylococcus aureus

被引：245

作者：

Stranger-Jones, Yukiko K. ^{[1
]}

Bae, Taeok ^{[1
]}

Schneewind, Olaf ^{[1
]}

机构：

[1] Univ Chicago, Dept Microbiol, Chicago, IL 60637 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 45期

关键词：

disease protection; opsonophagocytosis; reverse vaccinology;

D O I：

10.1073/pnas.0606863103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Staphylococcus aureus is the most common cause of hospital-acquired infection. Because of the emergence of anti biotic-resistant strains, these infections represent a serious public health threat. To develop a broadly protective vaccine, we tested cell wall-anchored surface proteins of S. aureus as antigens in a murine model of abscess formation. Immunization with four antigens (IsdA, IsdB, ScIrD, and SdrE) generated significant protective immunity that correlated with the induction of opsonophagocytic antibodies. When assembled into a combined vaccine, the four surface proteins afforded high levels of protection against invasive disease or lethal challenge with human clinical S. aureus isolates.

引用

页码：16942 / 16947

页数：6

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