Marine natural products and related compounds in clinical and advanced preclinical trials

被引：566

作者：

Newman, DJ ^{[1
]}

Cragg, GM ^{[1
]}

机构：

[1] NCI Frederick, Natl Prod Branch, Dev Therapeut Program, Frederick, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 08期

关键词：

D O I：

10.1021/np040031y

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The marine environment has proven to be a very rich source of extremely potent compounds that have demonstrated significant activities in antitumor, antiinflammatory, analgesia, immunomodulation, allergy, and anti-viral assays. Although the case can and has been made that the nucleosides such as Ara-A and Ara-C are derived from knowledge gained from investigations of bioactive marine nucleosides, no drug directly from marine sources (whether isolated or by total synthesis) has yet made it to the commercial sector in any disease. However, as shown in this review, there are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase II/III clinical trials in cancer, analgesia, allergy, and cognitive diseases. A substantial number of other potential agents are following in their wake in preclinical trials in these and in other diseases.

引用

页码：1216 / 1238

页数：23

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