Short synthetic route to the enantiomerically pure (R)-(+)-gamma-decalactone

被引：18

作者：

Kula, J

Sikora, M

Sadowska, H

Piwowarski, J

机构：

[1] Institute of General Food Chemistry, Technical University of Lodz

来源：

TETRAHEDRON | 1996年 / 52卷 / 34期

关键词：

D O I：

10.1016/0040-4020(96)00658-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient procedure for the preparation of homochiral (R)-(+)-gamma-decalactone 4 based on castor oil ozonolysis is described. The key intermediate, (R)-(-)-1,3-nonandiol 1, was transformed into monotosylate 1 and then reacted with sodium cyanide to give (R)-(-)-4-hydroxydecanitrile 3. Treatment of the latter with a dilute hydrochloric acid provided the enantiomerically pure lactone 4 Copyright (C) 1995 Elsevier Science Ltd

引用

页码：11321 / 11324

页数：4

共 13 条

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