Single nucleotide polymorphism libraries: why and how are we building them?

被引：104

作者：

Kwok, PY

Gu, ZJ

机构：

[1] Washington Univ, Sch Med, Div Dermatol, St Louis, MO 63110 USA

[2] Motorola BioCHip Syst, Northbrook, IL 60062 USA

来源：

MOLECULAR MEDICINE TODAY | 1999年 / 5卷 / 12期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S1357-4310(99)01601-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A great deal of time and money is currently being invested In the production of large libraries of single nucleotide polymorphisms (SNPs) - variations of one nucleotide between the DNA sequence of individuals. This review compares and contrasts the available sources of SNP data, and describes the rationale behind the SNP mapping efforts, from the study of common diseases to unraveling an individual's response to medication.

引用

收藏

页码：538 / 543

页数：6

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