Using nonnatural amino acids to control metal-coordination number in three-stranded coiled coils

被引：49

作者：

Lee, Kyung-Hoon

Cabello, Chris

Hemmingsen, Lars

Marsh, E. Neil G.

Pecoraro, Vincent L. ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[2] Royal Vet & Agr Univ, Dept Math & Phys, DK-1870 Frederiksberg, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 18期

关键词：

amino acids; cadmium; coordination modes; metalloproteins; peptides;

D O I：

10.1002/anie.200504548

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) It isn't natural: TRI peptides can selectively control the coordination number of a metal center by changing only one of the amino acids in the primary sequence. Replacement of the cysteine residue with penicillamine leads to a three-coordinate complex CdIIS3, whereas substitution of alanine for leucine gives four-coordinate CdS 3O (see scheme). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2864 / 2868

页数：5

共 37 条

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