Structure and process relationship of electrospun bioabsorbable nanofiber membranes

被引:1629
作者
Zong, XH
Kim, K
Fang, DF
Ran, SF
Hsiao, BS [1 ]
Chu, B
机构
[1] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA
[2] Stonybrook Technol & Appl Res Inc, Stony Brook, NY 11790 USA
关键词
electrospinning; poly(lactic acid); biodegradable nanofiber;
D O I
10.1016/S0032-3861(02)00275-6
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
An electrospinning method was used to fabricate bioabsorbable amorphous poly(D,L-lactic acid) (PDLA) and semi-crystalline poly(L-lactic acid) (PLLA) nanofiber non-woven membranes for biomedical applications. The structure and morphology of electrospun membranes were investigated by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and synchrotron wide-angle X-ray diffraction/small angle X-ray scattering. SEM images showed that the fiber diameter and the nanostructured morphology depended on processing parameters such as solution viscosity (e.g. concentration and polymer molecular weight), applied electric field strength, solution feeding rate and ionic salt addition. The combination of different materials and processing parameters could be used to fabricate bead-free nanofiber non-woven membranes. Concentration and salt addition were found to have relatively larger effects on the fiber diameter than the other parameters. DSC and X-ray results indicated that the electrospun PLLA nanofibers were completely non-crystalline but had highly oriented chains and a lower glass transition temperature than the cast film. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:4403 / 4412
页数:10
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