High level of resistance to metronidazole and clarithromycin in Helicobacter pylori isolated from pediatric patients in Poland (1997-2001)

被引：8

作者：

Gosciniak, G ^{[1
]}

Iwanczak, B ^{[1
]}

Przondo-Mordarska, A ^{[1
]}

Grabinska, J ^{[1
]}

Iwanczak, F ^{[1
]}

机构：

[1] Univ Med, Dept Microbiol, PL-50368 Wroclaw, Poland

来源：

FOLIA MICROBIOLOGICA | 2004年 / 49卷 / 02期

关键词：

D O I：

10.1007/BF02931386

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Resistance to metronidazole (Met), clarithromycin (Cla) and amoxycillin (Amo) was examined using H. pylori isolates from child patients before and after treatment in the period 1997-2001. The rate of Met and Cla resistance before treatment was 35.2 and 8.6%, respectively. Six weeks after treatment 48.4% of the isolated strains were resistant to Met and 17.6% to Cla. The highest rate of resistance to both antibiotics was determined in 2001 (before treatment, 46 and 15%, respectively, and after treatment, 57.8 and 26.3%, respectively). All the strains were susceptible to Amo. Strains resistant to Met were detected more frequently in girls than in boys.

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页码：133 / 136

页数：4

相关论文

共 16 条

[1] Clarithromycin resistance among Helicobacter pylori strains isolated from children:: Prevalence and study of mechanism of resistance by PCR-restriction fragment length polymorphism analysis [J].

Alarcón, T ;

Vega, AE ;

Domingo, D ;

Martínez, MJ ;

López-Brea, M .

JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (01) :486-488

[2] Primary and combined resistance to four antimicrobial agents in Helicobacter pylori in Sofia, Bulgaria [J].

Boyanova, L ;

Stancheva, I ;

Spassova, Z ;

Katzarov, N ;

Mitov, I ;

Koumanova, R .

JOURNAL OF MEDICAL MICROBIOLOGY, 2000, 49 (05) :415-418

[3] Features and trends in Helicobacter pylori antibiotic resistance in Lisbon area, Portugal (1990-1999) [J].

Cabrita, J ;

Oleastro, M ;

Matos, R ;

Manhente, A ;

Cabral, J ;

Barros, R ;

Lopes, AI ;

Ramalho, P ;

Neves, BC ;

Guerreiro, AS .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 46 (06) :1029-1031

[4] Helicobacter pylori in children and adolescents:: Increase of primary clarithromycin resistance, 1997-2000 [J].

Crone, J ;

Granditsch, G ;

Huber, WD ;

Binder, C ;

Innerhofer, A ;

Amann, G ;

Hirschl, AM .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2003, 36 (03) :368-371

[5]

Dore MP, 1998, ALIMENT PHARM THER, V12, P635

[6]

GLUPCZYNSKI Y, 1992, EUR J CLIN MICROBIOL, V11, P777

[7] Secondary resistance among 554 isolates of Helicobacter pylori after failure of therapy [J].

Heep, M ;

Kist, M ;

Strobel, S ;

Beck, D ;

Lehn, N .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2000, 19 (07) :538-541

[8] High levels of resistance to metronidazole and clarithromycin in Helicobacter pylori strains in children [J].

Kalach, N ;

Bergeret, M ;

Benhamou, PH ;

Dupont, C ;

Raymond, J .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (01) :394-397

[9] Regional differences in metronidazole resistance and increasing clarithromycin resistance among Helicobacter pylori isolates from Japan [J].

Kato, M ;

Yamaoka, Y ;

Kim, JJ ;

Reddy, R ;

Asaka, M ;

Kashima, K ;

Osato, MS ;

El-Zaatari, FAK ;

Graham, DY ;

Kwon, DH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (08) :2214-2216

[10] Characterization of the genes rdxA and frxA involved in metronidazole resistance in Helicobacter pylori [J].

Marais, A ;

Bilardi, C ;

Cantet, F ;

Mendz, GL ;

Mégraud, F .

RESEARCH IN MICROBIOLOGY, 2003, 154 (02) :137-144