Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes

被引：146

作者：

Zhang, Ping ^{[1
,2
]}

Zhang, Yan ^{[1
,2
,4
]}

Mao, Li ^{[1
,2
,3
]}

Zhang, Zhiyuan ^{[1
,2
]}

Chen, Wantao ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Sch Stomatol,Dept Oral & Maxillofacial Surg, Shanghai Key Lab Stomatol,Peoples Hosp 9, Shanghai 200011, Peoples R China

[2] Shanghai Res Inst Stomatol, Shanghai 200011, Peoples R China

[3] Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA

[4] Cent Hosp Xuhui Dist Shanghai, Dept Stomatol, Shanghai 200031, Peoples R China

来源：

CANCER LETTERS | 2009年 / 277卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Side population; Oral squamous cell carcinoma; Tumor; Stem cell; Phenotype; BINDING CASSETTE TRANSPORTER; IN-VITRO; CANCER; EXPRESSION; IDENTIFICATION; SUBPOPULATION; EFFLUX; LINES; HEAD; FORM;

D O I：

10.1016/j.canlet.2008.12.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

To characterize the biological features of side population (SP) in oral squamous cell carcinoma (OCC), SP and non-SP were sorted and compared. The SP cells were more clonogenic and in nude mice, only 10,000 SP cells were needed for tumor development compared to 1,000,000 non-SP cells. The SP cells expressed higher levels of ABCG2, ABCB1, CD44, Oct-4, Bmi-1, NSPc1 and CK19. The SP cells generated SP and non-SP populations, whereas the non-SP cells generated only non-SP. These findings provide the first evidence that SP in OCC possesses tumor stem cell phenotypes and may play an important role in OCC tumorigenesis. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：227 / 234

页数：8

共 31 条

[1]

Prospective identification of tumorigenic breast cancer cells [J].