BRCA1 and BRCA2:: 1994 and beyond

被引：674

作者：

Narod, SA

Foulkes, WD

机构：

[1] Sunnybrook & Womens Coll Hlth Sci Ctr, Ctr Res Womens Hlth, Toronto, ON M55 1N8, Canada

[2] McGill Univ, Dept Oncol, Program Canc Genet, Montreal, PQ H3G 1A4, Canada

[3] McGill Univ, Dept Human Genet, Program Canc Genet, Montreal, PQ H3G 1A4, Canada

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 09期

关键词：

D O I：

10.1038/nrc1431

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The discovery of the first gene associated with hereditary breast cancer, BRCA1, was anticipated to greatly increase our understanding of both hereditary and sporadic forms of breast cancer, and to lead to therapeutic and preventive breakthroughs. Much has been learned during the past decade about the genetic epidemiology of breast cancer, the ethnic distribution and clinical consequences of BRCA1 and BRCA2 mutations, and the central role of DNA repair in breast cancer susceptibility. The ability to translate this knowledge into novel treatments, however, remains elusive.

引用

页码：665 / 676

页数：12

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