Hydrogels: from controlled release to pH-responsive drug delivery

被引：1336

作者：

Gupta, P ^{[1
]}

Vermani, K ^{[1
]}

Garg, S ^{[1
]}

机构：

[1] NIPER, SAS Nagar 160062, Punjab, India

来源：

DRUG DISCOVERY TODAY | 2002年 / 7卷 / 10期

关键词：

D O I：

10.1016/S1359-6446(02)02255-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Besides exhibiting swelling-controlled drug release, hydrogels also show stimuli-responsive changes in their structural network and hence, the drug release. Because of large variations in physiological pH at various body sites in normal as well as pathological conditions, pH-responsive polymeric networks have been extensively studied. This review highlights the use of hydrogels (a class of polymeric systems) in controlled drug delivery, and their application in stimuli-responsive, especially pH-responsive, drug release.

引用

页码：569 / 579

页数：11

共 70 条

[21] KINETICS AND MECHANISMS OF WATER SORPTION IN HYDROPHOBIC, IONIZABLE COPOLYMER GELS [J].