Branching morphogenesis and kidney disease

被引:125
作者
Shah, MM
Sampogna, RV
Sakurai, H
Bush, KT
Nigam, SK [1 ]
机构
[1] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
来源
DEVELOPMENT | 2004年 / 131卷 / 07期
关键词
D O I
10.1242/dev.01089
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Branching morphogenesis in the kidney is a tightly regulated, complex process and its disruption potentially can lead to a broad spectrum of diseases, ranging from rare hereditary syndromes to common conditions such as hypertension and chronic kidney failure. This review synthesizes data on branching during kidney development derived from in vitro and in vivo rodent studies and to apply them to human diseases. It discusses how the broad organization of molecular interactions during kidney development might provide a mechanistic framework for understanding disorders related to aberrant branching.
引用
收藏
页码:1449 / 1462
页数:14
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