Revisiting the definition of somatic mutational status in B-cell tumors:: does 98% homology mean that a VH-gene is unmutated?

被引:16
作者
Forconi, F
Sahota, SS
Lauria, F
Stevenson, FK [1 ]
机构
[1] Southampton Univ Hosp Trust, Canc Sci Div, Tenovus Lab, Mol Immunol Grp, Southampton SO16 6YD, Hants, England
[2] Univ Siena, Dipartimento Med Clin & Sci Immunol, Div Imatol & Trapianti, I-53100 Siena, Italy
关键词
D O I
10.1038/sj.leu.2403312
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:882 / 883
页数:2
相关论文
共 8 条
[1]   SOMATIC MUTATION IN A CULTURED MOUSE MYELOMA CELL AFFECTS ANTIGEN-BINDING [J].
COOK, WD ;
RUDIKOFF, S ;
GIUSTI, AM ;
SCHARFF, MD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (04) :1240-1244
[2]   Tumor cells of hairy cell leukemia express multiple clonally related immunoglobulin isotypes via RNA splicing [J].
Forconi, F ;
Sahota, SS ;
Raspadori, D ;
Mockridge, CI ;
Lauria, F ;
Stevenson, FK .
BLOOD, 2001, 98 (04) :1174-1181
[3]   Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin VHDJH gene diversification [J].
Gurrieri, C ;
McGuire, P ;
Zan, H ;
Yan, XJ ;
Cerutti, A ;
Albesiano, E ;
Allen, SL ;
Vinciguerra, V ;
Rai, KR ;
Ferrarini, M ;
Casali, P ;
Chiorazzi, N .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (05) :629-639
[4]   Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia [J].
Hamblin, TJ ;
Davis, Z ;
Gardiner, A ;
Oscier, DG ;
Stevenson, FK .
BLOOD, 1999, 94 (06) :1848-1854
[5]   Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice [J].
Matsumoto, M ;
Lo, SF ;
Carruthers, CJL ;
Min, JJ ;
Mariathasan, S ;
Huang, GM ;
Plas, DR ;
Martin, SM ;
Geha, RS ;
Nahm, MH ;
Chaplin, DD .
NATURE, 1996, 382 (6590) :462-466
[6]   Splenic marginal zone lymphoma with villous lymphocytes shows on-going immunoglobulin gene mutations [J].
Tierens, A ;
Delabie, J ;
Malecka, A ;
Wang, JB ;
Gruszka-Westwood, A ;
Catovsky, D ;
Matutes, E .
AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (02) :681-689
[7]   Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers [J].
Toellner, KM ;
Jenkinson, WE ;
Taylor, DR ;
Khan, M ;
Sze, DMY ;
Sansom, DM ;
Vinuesa, CG ;
MacLennan, ICM .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (03) :383-389
[8]   Patterns of somatic mutations in VH genes reveal pathways of clonal transformation from MGUS to multiple myeloma [J].
Zojer, N ;
Ludwig, H ;
Fiegl, M ;
Stevenson, FK ;
Sahota, SS .
BLOOD, 2003, 101 (10) :4137-4139