A beneficial effect of oxandrolone in the treatment of Duchenne muscular dystrophy: A pilot study

被引：31

作者：

Fenichel, G ^{[1
]}

Pestronk, A ^{[1
]}

Florence, J ^{[1
]}

Robison, V ^{[1
]}

Hemelt, V ^{[1
]}

机构：

[1] WASHINGTON UNIV, SCH MED, DEPT NEUROL, ST LOUIS, MO 63110 USA

来源：

NEUROLOGY | 1997年 / 48卷 / 05期

关键词：

D O I：

10.1212/WNL.48.5.1225

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We treated 10 boys with Duchenne muscular dystrophy with oxandrolone, an anabolic steroid, for 3 months. The mean of the changes in the average muscle score was an improvement of 0.315 +/- 0.097. The expected mean change in muscle score after 3 months from natural history data is a loss of 0.1. The difference of 0.415 between the actual and expected values is significant at p < 0.01. This preliminary evidence suggests that oxandrolone treatment may provide a degree of functional benefit for children with Duchenne muscular dystrophy that is similar to that after prednisone administration.

引用

页码：1225 / 1226

页数：2

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