Antinociceptive Effect of Chlorogenic Acid in Rats with Painful Diabetic Neuropathy

被引：38

作者：

Bagdas, Deniz ^{[1
]}

Ozboluk, Hasret Yucel ^{[2
]}

Cinkilic, Nilufer ^{[3
]}

Gurun, Mine Sibel ^{[2
]}

机构：

[1] Uludag Univ, Fac Med, Expt Anim Breeding & Res Ctr, Bursa, Turkey

[2] Uludag Univ, Fac Med, Dept Pharmacol, Bursa, Turkey

[3] Uludag Univ, Fac Sci & Arts, Dept Biol, Bursa, Turkey

来源：

JOURNAL OF MEDICINAL FOOD | 2014年 / 17卷 / 06期

关键词：

antihyperalgesic; antinociceptive; chlorogenic acid; diabetes; diabetic neuropathy; pain;

D O I：

10.1089/jmf.2013.2966

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The present study aimed to evaluate possible antinociceptive effects of chlorogenic acid in streptozotocin-induced diabetic neuropathic pain in rats. Chlorogenic acid (100 mg/kg) was administered daily for 14 days. Our study showed for the first time that both single and chronic chlorogenic acid treatments produced significant antinociceptive effects in diabetic rats. In contrast, single dose of chlorogenic acid showed no signs of an antinociceptive effect, but chronic treatment exerted antinociceptive potential in nondiabetic rats. Additionally, chronic treatment effectively reduced hyperglycemia that induced by diabetes. In conclusion, chlorogenic acid has beneficial effects for the management of diabetic neuropathic pain.

引用

页码：730 / 732

页数：3

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