Enhancement of hyperthermia-induced apoptosis by non-thermal effects of ultrasound

被引：55

作者：

Feril, LB ^{[1
]}

Kondo, T ^{[1
]}

Zhao, QL ^{[1
]}

Ogawa, R ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Med, Dept Radiol Sci, Toyama 9300194, Japan

来源：

CANCER LETTERS | 2002年 / 178卷 / 01期

关键词：

apoptosis; hyperthermia; ultrasound; cancer therapy;

D O I：

10.1016/S0304-3835(01)00826-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To determine the effect of ultrasound on hyperthermia-induced apoptosis, we exposed U937 cells (in air-saturated suspension) to continuous 1 MHz ultrasound at intensities 0.5 or 1.0 W/cm(2), considered non-thermal and sub-threshold for inertial cavitation, while at 44.0degreesC for 10 min. We found that 0.5 W/cm(2), in combination with hyperthermia, synergistically induced apoptosis. On the other hand, 1.0 W/cm(2) in combination with hyperthermia showed an augmented instant cell lysis but no significant change in the ratio of apoptosis. This result might be useful when apoptosis induction is desired over instant cell killing in cancer therapy. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：63 / 70

页数：8

共 36 条

[1]

Ashush H, 2000, CANCER RES, V60, P1014

[2]

BARNETT S, 1998, ULTRASOUND MED BIOL, V24, pS29

[3] A PERFUSED TISSUE PHANTOM FOR ULTRASOUND HYPERTHERMIA [J].

BENKESER, PJ ;

FRIZZELL, LA ;

HOLMES, KR ;

GOSS, SA .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1990, 37 (04) :425-428

[4] Proteases for cell suicide: Functions and regulation of caspases [J].

Chang, HY ;

Yang, XL .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2000, 64 (04) :821-+

[5]

Dickson J A, 1982, Natl Cancer Inst Monogr, V61, P183

[6]

ELKON D, 1982, CANCER, V49, P25, DOI 10.1002/1097-0142(19820101)49:1<25::AID-CNCR2820490106>3.0.CO

[7]

2-A

[8] POTENTIAL OF LOCALIZED HEATING AS AN ADJUNCT TO RADIATION-THERAPY [J].

GERNER, EW ;

CONNOR, WG ;

BOONE, MLM ;

DOSS, JD ;

MAYER, EG ;

MILLER, RC .

RADIOLOGY, 1975, 116 (02) :433-439

[9]

HAHN GM, 1979, CANCER RES, V39, P2264

[10] THERMOCHEMOTHERAPY - SYNERGISM BETWEEN HYPERTHERMIA (42-43 DEGREES) AND ADRIAMYCIN (OR BLEOMYCIN) IN MAMMALIAN-CELL INACTIVATION [J].

HAHN, GM ;

BRAUN, J ;

HARKEDAR, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (03) :937-940

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