Yarrowia lipolytica: A model and a tool to understand the mechanisms implicated in lipid accumulation

被引：257

作者：

Beopoulos, Athanasios ^{[1
]}

Chardot, Thierry ^{[2
]}

Nicaud, Jean-Marc ^{[1
]}

机构：

[1] INRA, Lab Microbiol & Genet Mol, UMR 1238, CNRS,UMR2585,AgroParisTech,CBAI, F-78850 Thiverval Grignon, France

[2] INRA, Chim Biol Lab, UMR206, AgroParisTech,Ctr Biotechnol Agroind, F-78850 Thiverval Grignon, France

来源：

BIOCHIMIE | 2009年 / 91卷 / 06期

关键词：

Yarrowia lipolytica; Lipid accumulation; Triglycerides; Obesity; ACYL-COA OXIDASE; IDENTIFICATION; COENZYME;

D O I：

10.1016/j.biochi.2009.02.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The oleaginous yeast Yarrowia lipolytica is known to inhabit various lipid-containing environments. One of the most striking features in this yeast is the presence of several multigene families involved in the metabolic pathways of hydrophobic substrate utilization. The complexity and the multiplicity of these genes give Y. lipolytica a wide capability range towards hydrophobic substrate (HS) utilization and storage. The combination of the increasing knowledge of this yeast's metabolism and the development of more efficient genetic tools is offering new perspectives in using Y. lipolytica as a model organism to study the mechanisms involved in lipid metabolism associated to fat uptake, storage, deposition, mobilization and regulation. Nutrient status and culture conditions seem to play a major role in obesity. (c) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：692 / 696

页数：5

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