Molecular characterization of Pegarn: a Drosophila homolog of UNC-51 kinase

被引：10

作者：

Ahantarig, A. ^{[1
,2
]}

Chadwell, L. V. ^{[2
]}

Terrazas, I. B. ^{[2
]}

Garcia, C. T. ^{[2
]}

Nazarian, J. J. ^{[2
]}

Lee, H. K. ^{[2
]}

Lundell, M. J. ^{[2
]}

Cassill, J. A. ^{[2
]}

机构：

[1] Mahidol Univ, Fac Sci, Dept Biol, Bangkok 10400, Thailand

[2] Univ Texas San Antonio, Dept Biol, San Antonio, TX 78249 USA

来源：

MOLECULAR BIOLOGY REPORTS | 2009年 / 36卷 / 06期

关键词：

Uncoordinated movement-51; Ventral ganglion; Central nervous system; Commissures; Connectives; Midlines; CAENORHABDITIS-ELEGANS; CNS MIDLINE; GENETIC-ANALYSIS; GUIDANCE; IDENTIFICATION; ROUNDABOUT; FEATURES; DOMAINS; FAMILY; AXONS;

D O I：

10.1007/s11033-008-9314-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

We have isolated and characterized the gene encoding a Drosophila melanogaster homolog of Caenorhabditis elegans UNC-51 (uncoordinated movement-51): Pegarn. Developmental Northern blot shows the Pegarn gene is expressed at all stages of development. The protein is detected throughout the Drosophila third instar larval central nervous system (CNS) in axons projecting out from the ventral ganglion and in the optic anlagen of the optic lobe. Heterozygous Pegarn mutant embryos show defects in larval axonal neuronal patterning, but survive to adulthood. Homozygous mutants have an even more deformed pattern of neuronal development and do not survive through the larval stages. The data from this research suggest the critical roles of Pegarn in CNS and PNS axonal formation in Drosophila melanogaster and indicates its similar role in other multicellular species.

引用

页码：1311 / 1321

页数：11

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