Whole brain irradiation following surgery or radiosurgery for solitary brain metastases: Mature results of a prematurely closed randomized Trans-Tasman Radiation Oncology Group trial (TROG 98.05)

被引：58

作者：

Roos, Daniel E.

Wirth, Andrew

Burmeister, Bryan H.

Spry, Nigel A.

Drummond, Katharine J.

Beresford, Jennifer A.

McClure, Beverley E.

机构：

[1] Royal Adelaide Hosp, Dept Radiat Oncol, Adelaide, SA 5000, Australia

[2] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia

[3] Princess Alexandra Hosp, Woolloongabba, Qld, Australia

[4] Sir Charles Gairdner Hosp, Nedlands, WA 6009, Australia

[5] Royal Melbourne Hosp, Parkville, Vic 3050, Australia

[6] Peter MacCallum Canc Ctr, Ctr Biostat & Clin Trials, Melbourne, Vic, Australia

来源：

RADIOTHERAPY AND ONCOLOGY | 2006年 / 80卷 / 03期

关键词：

radiosurgery; solitary brain metastases; surgery; whole brain irradiation;

D O I：

10.1016/j.radonc.2006.08.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We evaluated the effect of adjuvant whole brain irradiation (WBI) after surgery or radiosurgery for solitary brain metastases in a Phase III multicentre trial with randomization to 30-36 Gy WBI or observation. The study was closed early due to slow accrual after 19 patients (WBI 10, observation 9). There was no difference in CNS failure-free survival or overall survival between the arms. There was a trend to reduced CNS relapse with WBI (30% versus 78%, P = 0.12). Limited analysis of quality of life and neurocognitive function data revealed no evidence of difference between the arms. Our results are not inconsistent with two larger randomized trials and support the use of upfront WBI to decrease brain recurrence in this setting. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：318 / 322

页数：5

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