Soluble Fc gamma receptor, Fc gamma RIIa2, is present in two forms in human serum and is increased in patients: with stage C chronic lymphocytic leukemia

被引：8

作者：

Astier, A ^{[1
]}

MerleBeral, H ^{[1
]}

delaSalle, H ^{[1
]}

Moncuit, J ^{[1
]}

Cazenave, JP ^{[1
]}

Fridman, WH ^{[1
]}

Hanau, D ^{[1
]}

Teillaud, JL ^{[1
]}

机构：

[1] INST CURIE,UNITE INSERM 255,PARIS,FRANCE

来源：

LEUKEMIA & LYMPHOMA | 1997年 / 26卷 / 3-4期

关键词：

B-CLL; chronic lymphocytic leukemia; Fc gamma RIIa2; human sera; secreted Fc gamma R;

D O I：

10.3109/10428199709051781

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human Fc gamma receptor type II (Fc gamma RII/CD32) can be produced in a soluble form, termed Fc gamma RIIa2, which contains the extra-and intracellular regions of the receptor, due to an alternative splicing of the transmembrane domain-encoding exon. We show that human sera contain two forms of Fc gamma RIIa2. A full-length secreted protein, which has a 32 kDa backbone, can be detected only in some sera while all sera contain a C-terminal truncated form, lacking part of the intracytoplasmic tail, and exhibiting a 24 kDa protein backbone. The 24 kDa form is significantly increased in sera from stage C patients with B chronic lymphocytic leukemia, compared to healthy donors, stage A and B CLL patients, or CLL patients in complete remission.

引用

页码：317 / 326

页数：10

共 39 条

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