Developmental regulation of membrane type-5 matrix metalloproteinase (MT5-MMP) expression in the rat nervous system

被引：43

作者：

Jaworski, DM ^{[1
]}

机构：

[1] Univ Vermont, Coll Med, Dept Anat & Neurobiol, Burlington, VT 05405 USA

来源：

BRAIN RESEARCH | 2000年 / 860卷 / 1-2期

关键词：

CNS; development; extracellular matrix; matrix metalloproteinase; MMP;

D O I：

10.1016/S0006-8993(00)02035-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An intricate balance between extracellular matrix (ECM) synthesis and degradation must be maintained during developmental tissue remodeling. Matrix metalloproteinases (MMPs) are the main mediators of ECM degradation. A subset of MMPs, referred to as membrane-type MMPs, contains a transmembrane domain that restricts protease activity at the cell surface. Membrane type-5 MMP is predominantly expressed in the brain. The present report is the first to demonstrate the temporal regulation and spatial distribution of MT5-MMP mRNA during nervous system development. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：174 / 177

页数：4

共 24 条

[1] Oligodendrocyte-type 2 astrocyte progenitors use a metalloendoprotease to spread and migrate on CNS myelin [J].

Amberger, VR ;

AvellanaAdalid, V ;

Hensel, T ;

BaronVanEvercooren, A ;

Schwab, ME .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (01) :151-162

[2] Membrane-type 1 matrix metalloprotease (MT1-MMP) enables invasive migration of glioma cells in central nervous system white matter [J].

Beliën, ATJ ;

Paganetti, PA ;

Schwab, ME .

JOURNAL OF CELL BIOLOGY, 1999, 144 (02) :373-384

[3]

Del Bigio MR, 1999, NEUROPATH APPL NEURO, V25, P54

[4]

Fowlkes John L., 1995, Progress in Growth Factor Research, V6, P255, DOI 10.1016/0955-2235(95)00017-8

[5]

FREDERIKSEN K, 1988, J NEUROSCI, V8, P1144

[6] MATRIX METALLOPROTEINASES AND PROCESSING OF PRO-TNF-ALPHA [J].

GEARING, AJH ;

BECKETT, P ;

CHRISTODOULOU, M ;

CHURCHILL, M ;

CLEMENTS, JM ;

CRIMMIN, M ;

DAVIDSON, AH ;

DRUMMOND, AH ;

GALLOWAY, WA ;

GILBERT, R ;

GORDON, JL ;

LEBER, TM ;

MANGAN, M ;

MILLER, K ;

NAYEE, P ;

OWEN, K ;

PATEL, S ;

THOMAS, W ;

WELLS, G ;

WOOD, LM ;

WOOLLEY, K .

JOURNAL OF LEUKOCYTE BIOLOGY, 1995, 57 (05) :774-777

[7]

HOCKFIELD S, 1985, J NEUROSCI, V5, P3310

[8] BEHAB, A NEW MEMBER OF THE PROTEOGLYCAN TANDEM REPEAT FAMILY OF HYALURONAN-BINDING PROTEINS THAT IS RESTRICTED TO THE BRAIN [J].

JAWORSKI, DM ;

KELLY, GM ;

HOCKFIELD, S .

JOURNAL OF CELL BIOLOGY, 1994, 125 (02) :495-509

[9] Intracranial injury acutely induces the expression of the secreted isoform of the CNS-specific hyaluronan-binding protein BEHAB brevican [J].

Jaworski, DM ;

Kelly, GM ;

Hockfield, S .

EXPERIMENTAL NEUROLOGY, 1999, 157 (02) :327-337

[10] Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript:: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts [J].

Kajita, M ;

Kinoh, H ;

Ito, N ;

Takamura, A ;

Itoh, Y ;

Okada, A ;

Sato, H ;

Seiki, M .

FEBS LETTERS, 1999, 457 (03) :353-356

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