Molecular control of the NEMO family of ubiquitin-binding proteins

被引：115

作者：

Clark, Kristopher ^{[1
]}

Nanda, Sambit ^{[1
]}

Cohen, Philip ^{[1
]}

机构：

[1] Univ Dundee, Coll Life Sci, Sir James Black Ctr, Phosphorylat & Ubiquitylat Unit,Med Res Council, Dundee DD1 5EH, Scotland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2013年 / 14卷 / 10期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

NF-KAPPA-B; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ANHIDROTIC ECTODERMAL DYSPLASIA; AMYOTROPHIC-LATERAL-SCLEROSIS; INTERFERON ANTIVIRAL RESPONSE; LINEAR POLYUBIQUITIN CHAINS; GENOME-WIDE ASSOCIATION; CHINESE HAN POPULATION; GAMMA-DEFICIENT MICE; OPEN-ANGLE GLAUCOMA;

D O I：

10.1038/nrm3644

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Research over the past decade has revealed how NF-kappa B essential modulator (NEMO; also known as IKK gamma) regulates the IKK alpha-IKK beta signalling axis in the innate immune system. The discovery that NEMO is a polyubiquitin-binding protein and that the IKK complex is modulated by other protein kinases that are themselves controlled by polyubiquitin chains has provided a deeper molecular understanding of the non-degradative roles of ubiquitylation. New mechanistic insights of NEMO and related polyubiquitin-binding proteins have become a paradigm for how the interplay between phosphorylation and ubiquitylation controls cell signalling networks in health and disease.

引用

页码：673 / 685

页数：13

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