Monitoring the Accumulation of Lipofuscin in Aging Murine Eyes by Fluorescence Spectroscopy

被引：14

作者：

Mukherjee, Prasun ^{[1
]}

Bose, Sayantan ^{[1
]}

Hurd, Alyse A. ^{[1
]}

Adhikary, Ramkrishna ^{[1
]}

Schonenbrucher, Holger ^{[2
]}

Hamir, Amir N. ^{[2
]}

Richt, Juergen A. ^{[2
]}

Casey, Thomas A. ^{[3
]}

Rasmussen, Mark A. ^{[3
,4
]}

Petrich, Jacob W. ^{[1
]}

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

[2] ARS, Virus & Pr Dis Livestock Res Unit, Natl Anim Dis Ctr, USDA, Ames, IA USA

[3] ARS, Preharvest Food Safety & Enter Dis Res Unit, Natl Anim Dis Ctr, USDA, Ames, IA USA

[4] SarTec Corp, Anoka, MN USA

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 2009年 / 85卷 / 01期

关键词：

AGE-RELATED-CHANGES; RETINAL-PIGMENT EPITHELIUM; CREUTZFELDT-JAKOB-DISEASE; TRANSMISSION; GRANULES; BLOOD; ABSORPTION; GENERATION; MELANIN; LIGHT;

D O I：

10.1111/j.1751-1097.2008.00425.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The integrated fluorescence of murine eyes is collected as a function of age. This fluorescence is attributed to pigments generally referred to as lipofuscin and is observed to increase with age. No difference in fluorescence intensity is observed between the eyes of males or females. This work provides a benchmark for further studies that are planned in order to use such signatures as markers of central nervous system (CNS) tissue or even of diseased CNS tissue and provides a basis for determining the age of a healthy animal.

引用

页码：234 / 238

页数：5

共 40 条

[1]

Seeing the wood through the trees: A review of techniques for distinguishing green fluorescent protein from endogenous autofluorescence [J].