Midterm benefits of left univentricular pacing in patients with congestive heart failure

Background - Resynchronization therapy by simultaneous pacing of the right and left ventricles has gained wide acceptance as a useful treatment for patients with severe congestive heart failure. Several short-term hemodynamic studies in humans and animals failed to demonstrate any benefit of biventricular pacing over left univentricular pacing, but long-term studies on this pacing mode are lacking. The objective of this study was to assess the outcome over a 1-year period of patients paced exclusively in the left ventricle. Methods and Results - Clinical, angiographic, echocardiographic, and ergometric data were collected at baseline and after 12 months in 22 patients (age, 69.3 +/- 6.5 years) with NYHA class III or IV (10 patients), sinus rhythm, left bundle-branch block, and no bradycardia indication for pacing. After 12 months, compared with baseline values, NYHA class improved significantly by 40% (P < 0.0001), 6-minute walk distance by 30% ( P = 0.01), peak (V) over dot O-2 by 26% ( P = 0.01), left ventricular end-diastolic diameter by 5% ( P = 0.02), ejection fraction by 22% ( P = 0.07), mitral regurgitation area by 40% ( P = 0.01), and norepinephrine level by 37% ( P = 0.04). Conclusions - In patients with severe congestive heart failure, sinus rhythm, and left bundle-branch block despite optimal pharmacological treatment, left univentricular pacing is feasible and results in significant midterm benefit in exercise tolerance and left ventricular function.