Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis

被引：285

作者：

Yao, HHC

Matzuk, MM

Jorgez, CJ

Menke, DB

Page, DC

Swain, A

Capel, B ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27708 USA

[2] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[5] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA

[6] MIT, Howard Hughes Med Inst, Whitehead Inst, Cambridge, MA 02139 USA

[7] MIT, Dept Biol, Cambridge, MA 02139 USA

[8] Inst Canc Res, Chester Beatty Labs, London SW3 6JB, England

来源：

DEVELOPMENTAL DYNAMICS | 2004年 / 230卷 / 02期

关键词：

sex determination; ovary; coelomic vessel; germ cells; follistatin; Wnt4;

D O I：

10.1002/dvdy.20042

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Wnt4(-/-) XX gonads display features normally associated with testis differentiation, suggesting that WNT4 actively represses elements of the male pathway during ovarian development. Here, we show that follistatin (Fst) which encodes a TGFbeta superfamily binding protein, is a downstream component of Wnt signaling. Fst inhibits formation of the XY-specific coelomic vessel in XX gonads. In addition, germ cells in the ovarian cortex are almost completely lost in both Wnt4 and Fst null gonads before birth. Thus, we propose that WNT4 acts through FST to regulate vascular boundaries and maintain germ cell survival in the ovary. (C) 2004 Wiley-Liss, Inc.

引用

页码：210 / 215

页数：6

共 39 条

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