Cytotoxic sesquiterpenoids from Eupatorium chinense

被引：42

作者：

Yang, SP ^{[1
]}

Huo, J ^{[1
]}

Wang, Y ^{[1
]}

Lou, LG ^{[1
]}

Yue, JM ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Drug Res, Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 04期

关键词：

D O I：

10.1021/np0304159

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten new sesquiterpenoids, namely, eupachinilides A-J (1-10), together with seven known sesquiterpenoids, eupachifolin D (11), budlein B (12), 8beta-(4'-hydroxytiglyloxy)-2beta-hydroxy-1alphaH,5alphaH,6betaH,7alphaH-guai-3,10(14),11(13)-trien-6,12-olide (13), 1,10-hydrobahia (14), 2alpha-hydroxyeupatolide (15), eupaserrin (16), and mollisorin B (17), were isolated from the whole plant of Eupatorium chinense. Their structures were elucidated mainly by spectral methods, especially 2D NMR techniques. Eupachinilides A (1), E (5), F (6), and I (9) exhibited moderate cytotoxic activities against several tumor cell lines. The structures assigned previously for eupachifolins B (11a), C (13a), and D (11) were revised by spectral analysis and 2D NMR techniques.

引用

页码：638 / 643

页数：6

共 18 条

[1]

*ADM BUR CHIN MED, 1998, CHIN MAT MED, V7, P833

[2] GUAIANOLIDES FROM ELEPHANTOPUS-CAROLINIANUS [J].