Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men

被引：70

作者：

Feltrin, Kate L.

Patterson, Michael

Ghatei, Mohammad A.

Bloom, Stephen R.

Meyer, James H.

Horowitz, Michael

Feinle-Bisset, Christine

机构：

[1] Univ Adelaide, Royal Adelaide Hosp, Dept Med, Adelaide, SA 5000, Australia

[2] Imperial Coll Sch Med, Fac Med, Dept Metab Med, London, England

来源：

PEPTIDES | 2006年 / 27卷 / 07期

基金：

英国医学研究理事会;

关键词：

fatty acid chain length; ghrelin; peptide YY; glucagon-like peptide-2; pancreatic polypeptide;

D O I：

10.1016/j.peptides.2006.01.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have evaluated the effects of fatty acid chain length on ghrelin, peptide YY (PYY), glucagon-like peptide-2 (GLP-2) and pancreatic polypeptide (PP) secretion and hypothesized that intraduodenal administration of dodecanoic ("C12"), but not decanoic ("C10"), acid would decrease plasma ghrelin and increase PYY, GLP-2 and PP concentrations. Plasma hormone concentrations were measured in seven healthy men during 90-min intraduodenal infusions of: (i) C12, (ii) C10 or (iii) control (rate: 2 ml/min, 0.375 kcal/min for C12/C10) and after a buffet-meal consumed following the infusion. C12 markedly suppressed plasma ghrelin and increased both PYY and GLP-2 (all P < 0.05) compared with control and C10, while C10 had no effect. Both C10 and C12 increased PP concentrations slightly (P < 0.05). We conclude that the effects of intraduodenal fatty acids on ghrelin, PYY and GLP-2 secretion are dependent on their chain length. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1638 / 1643

页数：6

共 40 条

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