Baylis-Hillman reaction assisted parallel synthesis of 3,5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents

被引：45

作者：

Batra, S ^{[1
]}

Roy, AK

Patra, A

Bhaduri, AP

Surin, WR

Raghavan, SAV

Sharma, P

Kapoor, K

Dikshit, M

机构：

[1] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Div Pharmacol, Lucknow 226001, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 09期

关键词：

Baylis-Hillman reaction; isoxazolecarbaldehyde; isoxazole; nucleophilic substitution; substituted piperazine; antithrombotic activity; platelet aggregation;

D O I：

10.1016/j.bmc.2004.02.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The solution-phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted -5-isoxazolecarb-aldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2059 / 2077

页数：19

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