Survival of hematological patients after discharge from the intensive care unit: a prospective observational study

被引：16

作者：

Bernal, Teresa ^{[1
,2
]}

Pardavila, Estefania V. ^{[1
]}

Bonastre, Juan ^{[3
]}

Jarque, Isidro ^{[4
]}

Borges, Marcio ^{[5
]}

Bargay, Joan ^{[6
]}

Ignacio Ayestaran, Jose ^{[7
]}

Insausti, Josu ^{[8
]}

Marcos, Pilar ^{[9
]}

Gonzalez-Sanz, Victor ^{[10
]}

Martinez-Camblor, Pablo ^{[11
]}

Albaiceta, Guillermo M. ^{[12
,13
,14
]}

机构：

[1] Hosp Univ Cent Asturias, Serv Hematol & Hemoterapia, Oviedo 33006, Spain

[2] Univ Oviedo, Dept Med, Oviedo, Spain

[3] Hosp Univ La Fe, Serv Med Intens, Valencia, Spain

[4] Hosp Univ La Fe, Serv Hematol, Valencia, Spain

[5] Hosp Son Llatzer, Serv Med Intens, Palma de Mallorca, Spain

[6] Hosp Son Llatzer, Serv Hematol, Palma de Mallorca, Spain

[7] Hosp Univ Son Espases, Serv Med Intens, Palma de Mallorca, Spain

[8] Hosp Navarra, Serv Med Intens, Pamplona, Spain

[9] Hosp Badalona Germans Trias & Pujol, Serv Med Intens, Badalona, Spain

[10] Hosp Univ Miguel Servet, Serv Med Intens, Zaragoza, Spain

[11] Oficina Invest Biosanitaria FICYT, Oviedo, Spain

[12] Hosp Univ Cent Asturias, Serv Med Intens, Oviedo, Spain

[13] Inst Salud Carlos III, CIBER Enfermedades Resp, Madrid, Spain

[14] Univ Oviedo, IUOPA, Dept Biol Func, Area Fisiol, Oviedo, Spain

来源：

CRITICAL CARE | 2013年 / 17卷 / 06期

关键词：

CRITICALLY-ILL PATIENTS; STEM-CELL TRANSPLANTATION; LONG-TERM OUTCOMES; NEUTROPENIC PATIENTS; RESPIRATORY-FAILURE; VENTILATORY SUPPORT; CANCER; MALIGNANCIES; LEUKEMIA; TRIAL;

D O I：

10.1186/cc13172

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Introduction: Although the survival rates of hematological patients admitted to the ICU are improving, little is known about the long-term outcome. Our objective was to identify factors related to long-term outcome in hematological patients after ICU discharge. Methods: A prospective, observational study was carried out in seven centers in Spain. From an initial sample of 161 hematological patients admitted to one of the participating ICUs during the study period, 62 were discharged alive and followed for a median time of 23 (1 to 54) months. Univariate and multivariate analysis were performed to identify the factors related to long term-survival. Finally, variables that influence the continuation of the scheduled therapy for the hematological disease were studied. Results: Mortality after ICU discharge was 61%, with a median survival of 18 (1 to 54) months. In the multivariate analysis, an Eastern Cooperative Oncology Group score (ECOG) >2 at ICU discharge (Hazard ratio 11.15 (4.626 to 26.872)), relapse of the hematological disease (Hazard ratio 9.738 (3.804 to 24.93)) and discontinuation of the planned treatment for the hematological disease (Hazard ratio 4.349 (1.286 to 14.705)) were independently related to mortality. Absence of stem cell transplantation, high ECOG and high Acute Physiology and Chronic Health Evaluation II (APACHE II) scores decreased the probability of receiving the planned therapy for the hematological malignancy. Conclusions: Both ICU care and post-ICU management determine the long-term outcome of hematological patients who are discharged alive from the ICU.

引用

页数：9

共 29 条

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