Insulin-mediated tyrosine phosphorylation of myosin heavy chain and concomitant enhanced association of C-terminal SRC kinase during skeletal muscle differentiation

被引：7

作者：

Goel, HL ^{[1
]}

Dey, CS ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Biotechnol, Signal Transduct Res Lab, SAS Nagar 160062, Punjab, India

来源：

CELL BIOLOGY INTERNATIONAL | 2002年 / 26卷 / 06期

关键词：

myosin heavy chain; insulin; tyrosine phosphorylation; Csk; myogenesis;

D O I：

10.1006/cbir.2002.0878

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this study, we present for the first time: (1) evidence regarding tyrosine phosphorylation of myosin heavy chain, (2) evidence that insulin can phosphorylate myosin, (3) association of myosin with Csk, a signalling molecule, (4) modulation of this association by insulin, and (5) evidence that these interactions are associated with skeletal muscle differentiation. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：557 / 561

页数：5

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