Synthesis of conjugates of L-fucose and ortho-carborane as potential agents for boron neutron capture therapy

The synthesis of three potential boron neutron capture therapy agents (6-8) is reported. The compounds synthesized are comprised of ortho-carborane covalently attached to L-fucose via C-6. Incorporation of the carborane moiety was achieved either through the reaction of an L-fucose-derived alkyne with decaborane or by the coupling of a 6-aminO-L-galactopyranose derivative with carborane carboxylic acid chloride (18).