Sphingomyelin-degrading pathways in human cells -: Role in cell signalling

被引：29

作者：

Levade, T

Andrieu-Abadie, N

Ségui, B

Augé, N

Chatelut, M

Jaffrézou, JP

Salvayre, R

机构：

[1] CHU Rangueil, Inst Louis Bugnard, Lab Biochim Malad Metab, INSERM,U466, F-31403 Toulouse 4, France

[2] Inst Claudius Regaud, INSERM, E 9910, Toulouse, France

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1999年 / 102卷 / 1-2期

关键词：

sphingomyelin; sphingomyelinase; lysosome; Niemann-Pick disease; ceramide; signalling;

D O I：

10.1016/S0009-3084(99)00085-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ubiquitous sphingophospholipid sphingomyelin (SM) can be hydrolysed in human cells to ceramide by different sphingomyelinases (SMases). These enzymes exert a dual role, enabling not only the turnover of membrane SM and the degradation of exogenous (lipoprotein) SM, but also the signal-induced generation of the lipid second messenger ceramide. This review focuses on the function(s) of the different SMases in living cells. While both lysosomal and non-lysosomal pathways that ensure SM hydrolysis in intact cells can be distinguished, the precise contribution of each of these SM-cleaving enzymes to the production of ceramide as a signalling molecule remains to be clarified. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

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收藏

页码：167 / 178

页数：12

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