Sequential catecholamine and serotonin depletion in mirtazapine-treated depressed patients

被引：33

作者：

Delgado, PL ^{[1
]}

Moreno, FA ^{[1
]}

Onate, L ^{[1
]}

Gelenberg, AJ ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Psychiat, Sch Med, Cleveland, OH 44106 USA

来源：

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2002年 / 5卷 / 01期

关键词：

antidepressant; major depression; neurotransmitter depletion; norepinephrine; selective serotonin reuptake inhibitors; sexual dysfunction;

D O I：

10.1017/S1461145702002778

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study was aimed at determining whether patient- or antidepressant-related variables are most important to the mood response to serotonin (5-HT) or catecholamine depletion. Depressed patients treated with open-label mirtazapine (greater than or equal to 6 wk) received two depletion tests (5-HT and catecholamine depletion) I wk apart, Both 5-HT and catecholamine depletion led to a partial return of depression in most patients. Antidepressant response to mirtazapine is dependent on its dual actions on norepmephrine and 5-HT neurotransmission. Mood response to tryptophan or catecholamine depletion is dependent on the pharmacological properties of the antidepressant being taken during depletion.

引用

页码：63 / 66

页数：4

共 8 条

[1]

deBoer T, 1996, J CLIN PSYCHIAT, V57, P19

[2]

DELGADO PL, 1990, ARCH GEN PSYCHIAT, V47, P411

[3] Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: Implications for the role of serotonin in the mechanism of antidepressant action [J].

Delgado, PL ;

Miller, HL ;

Salomon, RM ;

Licinio, J ;

Krystal, JH ;

Moreno, FA ;

Heninger, GR ;

Charney, DS .

BIOLOGICAL PSYCHIATRY, 1999, 46 (02) :212-220

[4] Mirtazapine substitution in SSRI-induced sexual dysfunction [J].

Gelenberg, AJ ;

Laukes, C ;

McGahuey, C ;

Okayli, G ;

Moreno, F ;

Zentner, L ;

Delgado, P .

JOURNAL OF CLINICAL PSYCHIATRY, 2000, 61 (05) :356-360

[5]

MAZURE C, 1986, ARCH GEN PSYCHIAT, V43, P451

[6]

Miller HL, 1996, ARCH GEN PSYCHIAT, V53, P117

[7] Diagnostic and Statistical Manual of Mental Disorders [J].

Mittal, Vijay A. ;

Walker, Elaine F. .

PSYCHIATRY RESEARCH, 2011, 189 (01) :158-159

[8] Relapse of depression after rapid depletion of tryptophan [J].

Smith, KA ;

Fairburn, CG ;

Cowen, PJ .

LANCET, 1997, 349 (9056) :915-919

← 1 →