CaMKII and a failing strategy for growth in heart

被引：50

作者：

Anderson, Mark E. ^{[1
,2
]}

机构：

[1] Univ Iowa, Dept Internal Med, Div Cardiovasc Med, Carver Coll Med, Iowa City, IA 52242 USA

[2] Univ Iowa, Carver Coll Med, Dept Mol Physiol & Biophys, Iowa City, IA 52242 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2009年 / 119卷 / 05期

关键词：

CALMODULIN KINASE-II; CARDIAC-HYPERTROPHY; INDEPENDENT ACTIVATION; INHIBITION PROTECTS; FAILURE; CARDIOMYOPATHY; HYPERTENSION; DYSFUNCTION; MYOCARDIUM; CHANNELS;

D O I：

10.1172/JCI39262

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Patients with systolic left ventricular dysfunction die progressively from congestive heart failure or die suddenly from cardiac arrhythmias. Myocardial hypertrophy is an early event in most forms of heart failure, but the majority of patients with myocardial hypertrophy do not develop heart failure. Developing improved therapies for targeting the cell signaling pathways that enable this deadly transition from early myocardial insult to heart failure and sudden death is a key goal for improving public health. In this issue of the JCI, Ling and colleagues provide new evidence that activation of the multifunctional Ca(2+)/calmodulin-dependent kinase II delta is a decisive step on the path to heart failure in mice (see the related article beginning on page 1230).

引用

页码：1082 / 1085

页数：4

共 23 条

[1] Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure [J].

Ai, X ;

Curran, JW ;

Shannon, TR ;

Bers, DM ;

Pogwizd, SM .

CIRCULATION RESEARCH, 2005, 97 (12) :1314-1322

[2] The δ isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload [J].

Backs, Johannes ;

Backs, Thea ;

Neef, Stefan ;

Kreusser, Michael M. ;

Lehmann, Lorenz H. ;

Patrick, David M. ;

Grueter, Chad E. ;

Qi, Xiaoxia ;

Richardson, James A. ;

Hill, Joseph A. ;

Katus, Hugo A. ;

Bassel-Duby, Rhonda ;

Maier, Lars S. ;

Olson, Eric N. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (07) :2342-2347

[3] Prognostic significance of plasma norepinephrine in patients with asymptomatic left ventricular dysfunction [J].

Benedict, CR ;

Shelton, B ;

Johnstone, DE ;

Francis, G ;

Greenberg, B ;

Konstam, M ;

Probstfield, JL ;

Yusuf, S .

CIRCULATION, 1996, 94 (04) :690-697

[4] Increased left ventricular mass is a risk factor for the development of a depressed left ventricular ejection fraction within five years [J].

Drazner, MH ;

Rame, JE ;

Marino, EK ;

Gottdiener, JS ;

Kitzman, DW ;

Gardin, JM ;

Manolio, TA ;

Dries, DL ;

Siscovick, DS .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (12) :2207-2215

[5] RETRACTED: Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels (Retracted Article) [J].

Dzhura, I ;

Wu, YJ ;

Colbran, RJ ;

Balser, JR ;

Anderson, ME .

NATURE CELL BIOLOGY, 2000, 2 (03) :173-177

[6] A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation [J].

Erickson, Jeffrey R. ;

Joiner, Mei-ling A. ;

Guan, Xiaoqun ;

Kutschke, William ;

Yang, Jinying ;

Oddis, Carmine V. ;

Bartlett, Ryan K. ;

Lowe, John S. ;

O'Donnell, Susan E. ;

Aykin-Burns, Nukhet ;

Zimmerman, Matthew C. ;

Zimmerman, Kathy ;

Ham, Amy-Joan L. ;

Weiss, Robert M. ;

Spitz, Douglas R. ;

Shea, Madeline A. ;

Colbran, Roger J. ;

Mohler, Peter J. ;

Anderson, Mark E. .

CELL, 2008, 133 (03) :462-474

[7] ABNORMAL INTRACELLULAR CALCIUM HANDLING IN MYOCARDIUM FROM PATIENTS WITH END-STAGE HEART-FAILURE [J].

GWATHMEY, JK ;

COPELAS, L ;

MACKINNON, R ;

SCHOEN, FJ ;

FELDMAN, MD ;

GROSSMAN, W ;

MORGAN, JP .

CIRCULATION RESEARCH, 1987, 61 (01) :70-76

[8] Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy [J].

Khoo, Michelle S. C. ;

Li, Jingdong ;

Singh, Madhu V. ;

Yang, Yingbo ;

Kannankeril, Prince ;

Wu, Yuejin ;

Grueter, Chad E. ;

Guan, Xiaoqun ;

Oddis, Carmine V. ;

Zhang, Rong ;

Mendes, Lisa ;

Ni, Gemin ;

Madu, Ernest C. ;

Yang, Jinying ;

Bass, Martha ;

Gomez, Rey J. ;

Wadzinski, Brian E. ;

Olson, Eric N. ;

Colbran, Roger J. ;

Anderson, Mark E. .

CIRCULATION, 2006, 114 (13) :1352-1359

[9] The progression from hypertension to congestive heart failure [J].

Levy, D ;

Larson, MG ;

Vasan, RS ;

Kannel, WB ;

Ho, KKL .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 275 (20) :1557-1562

[10] Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice [J].

Ling, Haiyun ;

Zhang, Tong ;

Pereira, Laetitia ;

Means, Christopher Kable ;

Cheng, Hongqiang ;

Gu, Yusu ;

Dalton, Nancy D. ;

Peterson, Kirk L. ;

Chen, Ju ;

Bers, Donald ;

Brown, Joan Heller .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (05) :1230-1240

← 1 2 3 →