Cadherins: an integral role in inflammatory bowel disease and mucosal restitution

被引：42

作者：

Zbar, AP

Simopoulos, C

Karayiannakis, AJ

机构：

[1] Democritus Univ Thrace, Sch Med, Dept Surg 2, Alexandroupolis 68100, Greece

[2] Univ W Indies, Dept Surg, Sch Clin Med & Res, Bridgetown, Barbados

来源：

JOURNAL OF GASTROENTEROLOGY | 2004年 / 39卷 / 05期

关键词：

E-cadherin; catenins; cell adhesion; inflammatory bowel disease; mucosal restitution; trefoil peptides;

D O I：

10.1007/s00535-004-1335-8

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The intestinal epithelium is characterized by rapid cellular turnover with continuous proliferation of multipotential stem cells within Lieberkuhn's crypts, cellular migration along the crypt-villus axis, cellular differentiation, polarization, apical apoptosis, and luminal shedding. These processes are critical for the development and maintenance of normal intestinal epithelial architecture and function and involve complex cell-cell and cell-substratum interactions, which are mediated by epithelial (E)-cadherin and the integrins, respectively. This review outlines the role of E-cadherin and its cytoplasmic binding proteins, the catenins, as well as the interplay with other mucosal adhesion and restitution molecules during physiological processes in the intestinal epithelium mediating embryogenesis, cellular differentiation, cellular migration, and mucosal repair, as well as what is known about the dysregulation of assembly of the E-cadherin-catenin adhesion complex in inflammatory bowel disease.

引用

页码：413 / 421

页数：9

共 100 条

[1] EXPERIMENTAL ULCERATION LEADS TO SEQUENTIAL EXPRESSION OF SPASMOLYTIC POLYPEPTIDE, INTESTINAL TREFOIL FACTOR, EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH-FACTOR-ALPHA MESSENGER-RNAS IN RAT STOMACH [J].