Methylation of exon 2 of p16 is associated with late stage oesophageal cancer

被引：17

作者：

Kempster, S

Phillips, WA ^{[1
]}

Baindur-Hudson, S

Thomas, RJS

Dow, C

Rockman, SP

机构：

[1] Univ Melbourne, Western Hosp, Dept Surg, Footscray, Vic 3011, Australia

[2] Victoria Univ, Sch Life Sci & Technol, Werribee, Vic 3030, Australia

[3] Univ Melbourne, Dept Anat Pathol, Werribee, Vic 3030, Australia

来源：

CANCER LETTERS | 2000年 / 150卷 / 01期

关键词：

oesophageal cancer; methylation; p16(INK4a); CDKN2A; p14(ARF);

D O I：

10.1016/S0304-3835(99)00372-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Methylation of the p16 gene was studied in 16 oesophageal tumours. Five (31%) of the tumours were found to be methylated in exon 1 and eight (50%) were methylated in exon 2. The loss of p16 protein correlated with methylation of exon 1 (P = 0.005). However, methylation of exon 2, but not exon 1, was found to be associated with late stage tumours (P = 0.01). We conclude that the methylation of exon 2 of p16 may have effects on the progression of oesophageal tumours that are independent of the expression of the p16 protein. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：57 / 62

页数：6

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