Stylissadines A and B:: The first tetrameric pyrrole-imidazole alkaloids

被引：69

作者：

Grube, Achim ^{[1
]}

Koeck, Matthias ^{[1
]}

机构：

[1] Alfred Wegener Inst Polar & Meeresforsh Helmholtz, D-27570 Bremerhaven, Germany

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 21期

关键词：

D O I：

10.1021/ol061317s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrrole - imidazole alkaloids are widely distributed in marine sponges of the orders Halichondrida and Agelasida. Chemical investigation of the Caribbean sponge Stylissa caribica led to the isolation of the first tetrameric pyrrole - imidazole alkaloids. The so-called stylissadines are the largest and most complex pyrrole - imidazole alkaloids discovered so far and are therefore a major challenge for the structure determination by NMR spectroscopy. Their isolation and structure elucidation are discussed in detail.

引用

页码：4675 / 4678

页数：4

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