Understanding arsenic metabolism through a comparative study of arsenic levels in the urine, hair and fingernails of healthy volunteers from three unexposed ethnic groups in the United Kingdom

被引:102
作者
Brima, Eid I.
Haris, Parvez I.
Jenkins, Richard O.
Polya, Dave A.
Gault, Andrew G.
Harrington, Chris F.
机构
[1] De Montfort Univ, Sch Allied Hlth Sci, Fac Hlth & Life Sci, Leicester LE1 9BH, Leics, England
[2] Univ Manchester, Sch Earth Atmospher & Environm Sci, Manchester M13 9PL, Lancs, England
[3] Univ Manchester, Williamson Res Ctr Mol Environm Sci, Manchester M13 9PL, Lancs, England
[4] Univ Leicester, Canc Biomarkers & Prevent Grp, Bioctr, Leicester LE1 7RH, Leics, England
基金
英国工程与自然科学研究理事会;
关键词
arsenic in human urine; HPLC-ICP-MS; arsenic speciation; diet; ethnicity; arsenic in hair; arsenic in fingernail; GF-AAS; dimethylarsinate;
D O I
10.1016/j.taap.2006.04.004
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Very little is known about arsenic (As) metabolism in healthy populations that are not exposed to high concentrations of As in their food or water. Here we present a study with healthy volunteers from three different ethnic groups, residing in Leicester, UK, which reveals statistically significant differences in the levels of total As in urine and fingernail samples. Urine (n = 63), hair (n = 36) and fingernail (n = 36) samples from Asians, Somali Black-Africans and Whites were analysed using inductively coupled plasma mass spectrometry (ICP-MS) and graphite furnace atomic absorption spectroscopy (GF-AAS). The results clearly show that the total concentrations of As in urine and fingernail samples of a Somali Black-African population (urine 7.2 mu g/g creatinine; fingernails 723.1 mu g/kg) are significantly (P < 0.05) different from the Asian (urine 20.6 mu g/g creatinine; fingernails 153.9 mu g/kg) and White groups (urine 24.5 mu g/g creatinine; fingernails 177.0 mu g/kg). The chemical speciation of As in the urine of the three groups was also measured using high performance liquid chromatography coupled to ICP-MS. This showed that the proportion of the total urinary As present as dimethylarsenate (DMA) was higher for the Somali Black-African group (50%) compared to the Asians (16%) and Whites (22%). However, there was no significant difference (P > 0.05) in the level of As in the hair samples from these three groups; Somali Black-Africans (116.0 mu g/kg), Asians (117.4 mu g/kg) and Whites (141.2 mu g/kg). Significantly different levels of total As in fingernail and urine and a higher percentage of urinary DMA in the Somali Black-Africans are suggestive of a different pattern of As metabolism in this ethnic group. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:122 / 130
页数:9
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