Plasma aldosterone concentrations are not related to the degree of angiotensin-converting enzyme inhibition in essential hypertensive patients

被引:27
作者
Sato, A
Suzuki, Y
Shibata, H
Saruta, T
机构
[1] Mito Red Cross Hosp, Dept Internal Med, Mito, Ibaraki 3100011, Japan
[2] Keio Univ, Dept Internal Med, Tokyo, Japan
关键词
plasma aldosterone concentrations; angiotensin-converting enzyme inhibitor; essential hypertension; angiotensin II; plasma angiotensin-converting enzyme activity;
D O I
10.1291/hypres.23.25
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
There is increasing evidence of important cardiovascular effects of aldosterone via classical mineralocorticold receptors in the heart. Aldosterone plus excess salt administration has been shown to produce both cardiac hypertrophy and cardiac fibrosis in rats. Various clinical studies have reported that aldosterone plays an important role in cardiac hypertrophy; however, the factors that control plasma aldosterone concentrations during angiotensin-converting enzyme (ACE) inhibitor treatment have still not been established. In the present study, we examined the relationship between plasma aldosterone concentrations and the degree of ACE inhibition in 25 essential hypertensive patients treated with an ACE inhibitor. Blood pressure decreased with treatment and plasma ACE activity, estimated in vitro (by a colorimetric method) and in vivo (by plasma angiotensin II/angiotensin I ratio) assay, was suppressed compared with that of hypertensive patients treated with medication other than ACE-inhibitors, No relationship was found be tween the level of ACE inhibition and plasma aldosterone concentrations, which rose in parallel with the duration of ACE inhibitor treatment, The present study demonstrates that continuous ACE inhibitor therapy produces significant suppression of plasma ACE activity:in essential hypertensive patients, but that no relationship exists between plasma aldosterone concentrations and levels of ACE inhibition. Plasma aldosterone concentrations tend to increase with the duration of ACE inhibitor treatment, although this increase did not reflect a reduced inhibition of ACE activity.
引用
收藏
页码:25 / 31
页数:7
相关论文
共 37 条
[1]  
[Anonymous], 1997, ARCH INTERN MED, V157, P2413, DOI DOI 10.1001/ARCHINTE.1997.00440420033005
[2]   DISCORDANT EFFECTS OF ENALAPRIL AND LISINOPRIL ON SYSTEMIC AND RENAL HEMODYNAMICS [J].
APPERLOO, AJ ;
DEZEEUW, D ;
DEJONG, PE .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1994, 56 (06) :647-658
[3]   High plasma level of N-acetyl-seryl-aspartyl-lysyl-proline - A new marker of chronic angiotensin-converting enzyme inhibition [J].
Azizi, M ;
Ezan, E ;
Nicolet, L ;
Grognet, JM ;
Menard, J .
HYPERTENSION, 1997, 30 (05) :1015-1019
[4]  
BRILLA CG, 1992, J LAB CLIN MED, V120, P893
[5]   VALUE OF DIFFERENT CLINICAL AND BIOCHEMICAL CORRELATES TO ASSESS ANGIOTENSIN-CONVERTING ENZYME-INHIBITION [J].
DELACRETAZ, E ;
NUSSBERGER, J ;
PUCHLER, K ;
WOOD, AJ ;
ROBINSON, PR ;
WAEBER, B ;
BRUNNER, HR .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1994, 24 (03) :479-485
[6]   ECHOCARDIOGRAPHIC DETERMINATION OF LEFT-VENTRICULAR MASS IN MAN - ANATOMIC VALIDATION OF METHOD [J].
DEVEREUX, RB ;
REICHEK, N .
CIRCULATION, 1977, 55 (04) :613-618
[7]   INFLUENCE OF ARTERIAL BLOOD-PRESSURE AND ALDOSTERONE ON LEFT-VENTRICULAR HYPERTROPHY IN MODERATE ESSENTIAL-HYPERTENSION [J].
DUPREZ, DA ;
BAUWENS, FR ;
DEBUYZERE, ML ;
DEBACKER, TL ;
KAUFMAN, JM ;
VANHOECKE, J ;
VERMEULEN, A ;
CLEMENT, DL .
AMERICAN JOURNAL OF CARDIOLOGY, 1993, 71 (03) :A17-A20
[8]   ANGIOTENSIN-I CONVERTING ENZYME AND THE CHANGES IN OUR CONCEPTS THROUGH THE YEARS - DAHL,LEWIS,K. MEMORIAL LECTURE [J].
ERDOS, EG .
HYPERTENSION, 1990, 16 (04) :363-370
[9]   SUBCELLULAR MECHANISMS IN ACTION OF ADRENAL STEROIDS [J].
FELDMAN, D ;
EDELMAN, IS ;
FUNDER, JW .
AMERICAN JOURNAL OF MEDICINE, 1972, 53 (05) :545-+
[10]   Aldosterone, salt and cardiac fibrosis [J].
Funder, JW .
CLINICAL AND EXPERIMENTAL HYPERTENSION, 1997, 19 (5-6) :885-899