(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu(5), but not mGlu(1), receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus

被引：281

作者：

Doherty, AJ

Palmer, MJ

Henley, JM

Collingridge, GL

Jane, DE

机构：

[1] UNIV BRISTOL, SCH MED SCI, DEPT ANAT, BRISTOL BS8 1TD, AVON, ENGLAND

[2] UNIV BRISTOL, SCH MED SCI, DEPT PHARMACOL, BRISTOL BS8 1TD, AVON, ENGLAND

来源：

NEUROPHARMACOLOGY | 1997年 / 36卷 / 02期

关键词：

metabotropic glutamate receptors; N-methyl-D-aspartate; phenylglycines;

D O I：

10.1016/S0028-3908(97)00001-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A new phenylglycine derivative, (RS)-2-chloro-5-hydroxyphenylglycine (CHPG), has been synthesized and shown to selectively activate mGlu(5a) receptors, compared to mGlu(1 alpha) receptors, when expressed in CHO cells. This selective mGlu(5) receptor agonist also potentiates NMDA-induced depolarizations in rat hippocampal slices. CHPG may be a useful tool for studying the role of mGlu(5) receptors in the central nervous system. (C) 1997 Elsevier Science Ltd.

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收藏

页码：265 / 267

页数：3

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