The kinetoplastida endocytic apparatus. Part I: a dynamic system for nutrition and evasion of host defences

被引:59
作者
Morgan, GW
Hall, BS
Denny, PW
Carrington, M
Field, MC
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Sci Biol, Wellcome Trust Labs Mol Parasitol, London SW7 2AY, England
[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
基金
英国惠康基金;
关键词
D O I
10.1016/S1471-4922(02)02391-7
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
The endocytic system of kinetoplastid parasites is a highly polarized membrane network focused on the flagellar pocket localized at one end of the cell. When first characterized, the endosomal network was envisioned as a simple system for uptake of extracellular material by fluid-phase or receptor-mediated mechanisms. Subsequently, it has become clear that the kinetoplastid endosomal system has an active and vital role in avoiding the host immune system and virulence, as well as providing the basic functions to fulfil cellular nutritional requirements. In two reviews, recent advances in the definition and comprehension of kinetoplastida endocytosis are discussed and, in Trypanosoma brucei in particular as the more developed experimental system. In Part 1, the endocytic system is considered in context of the surface molecules and their potential roles in virulence.
引用
收藏
页码:491 / 496
页数:6
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