Immobilization of Coacervate Microcapsules in Multilayer Sodium Alginate Beads for Efficient Oral Anticancer Drug Delivery

被引：83

作者：

Feng, Chao ^{[1
]}

Song, Ruixi ^{[1
]}

Sun, Guohui ^{[1
]}

Kong, Ming ^{[1
]}

Bao, Zixian ^{[1
]}

Li, Yang ^{[1
]}

Cheng, Xiaojie ^{[1
]}

Cha, Dongsu ^{[2
]}

Park, Hyunjin ^{[2
]}

Chen, Xiguang ^{[1
]}

机构：

[1] Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Shandong, Peoples R China

[2] Korea Univ, Grad Sch Biotechnol, Seoul 136701, South Korea

来源：

BIOMACROMOLECULES | 2014年 / 15卷 / 03期

基金：

中国国家自然科学基金;

关键词：

IN-VITRO; CHITOSAN NANOPARTICLES; CARBOXYMETHYL CHITOSAN; OPTIMIZATION; FORMULATION; DOXORUBICIN; SYSTEMS;

D O I：

10.1021/bm401890x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

We have designed and evaluated coacervate microcapsules-immobilized multilayer sodium alginate beads (CMs-M-ALG-Beads) for oral drug delivery. The CMs-M-ALG-Beads were prepared by immobilization of doxorubicin hydrochloride (DOX) loaded chitosan/carboxymethyl coacervate microcapsules (DOX:CS/CMCS-CMs) in the core and layers of the multilayer sodium alginate beads. The obtained CMs-M-ALG-beads exhibited layer-by-layer structure and rough surface with many nanoscale particles. The swelling characteristic and drug release results indicated that 4-layer CMs-M-ALG-Beads possessed favorable gastric acid tolerance (the swelling rate <5%, the cumulative drug release rate <3.8%). In small intestine, the intact DOX:CS/CMCS-CMs were able to rapidly release from CMs-M-ALG-Beads with the dissolution of ALG matrix. Ex vivo intestinal mucoadhesive and permeation showed that CMs-M-ALG-Beads exhibited continued growth for P-app values of DOX, which was 1.07-1.15 folds and 1.28-1.38 folds higher than DOX:CS:CMCS-CMs in rat jejunum and ileum, respectively, demonstrating that CMs-M-ALG-Beads were able to enhance the absorption of DOX by controlled releasing DOX:CS/CMCS-CMs and prolonging the contact time between the DOX:CS/CMCS-CMs and small intestinal mucosa.

引用

页码：985 / 996

页数：12

共 33 条

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