Reevaluation of the role of HWP1 in systemic candidiasis by use of Candida albicans strains with selectable marker URA3 targeted to the ENO1 locus

被引：94

作者：

Sundstrom, P

Cutler, JE

Staab, JF

机构：

[1] Ohio State Univ, Coll Med & Publ Hlth, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Microbiol, Columbus, OH 43210 USA

[3] Montana State Univ, Dept Microbiol, Bozeman, MT 59717 USA

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 06期

关键词：

D O I：

10.1128/IAI.70.6.3281-3283.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previous evaluation of HWP1 in systemic candidiasis in CBA/J mice was done with Candida albicans strains with differing genetic locations of URA3 as a result of Ura-blaster mutagenesis. In this study, the presence of HWP1 and the location of UP,43 contributed to the severity of murine systemic candidiasis in BALB/c mice.

引用

页码：3281 / 3283

页数：3

共 8 条

[1] CAP1, an adenylate cyclase-associated protein gene, regulates bud-hypha transitions, filamentous growth, and cyclic AMP levels and is required for virulence of Candida albicans [J].