Liquid phase microextraction in a single drop of organic solvent by using a conventional microsyringe

Two modes of liquid-phase microextraction (LPME) were developed for capillary gas chromatography, Both methodologies, i.e., static LPME and dynamic LPME, involve the use of very small amounts of organic solvent (<2 mu L) in a conventional microsyringe, The performance of the two techniques is demonstrated in the determination of two chlorobenzenes extracted into a single drop of toluene by the use of a 10-mu L syringe, Static LPME provided some enrichment (similar to 12-fold), good reproducibility (9.7%), and simplicity but suffered relatively long extraction time (15 min), Dynamic LPME provided higher (similar to 27-fold) enrichment within much shorter extraction time (similar to 3 min), and relatively poorer precision (12.8%), primarily due to repeated manual manipulation, Both methods allow the direct transfer of extracted analytes into a gas chromatograph.